Tetrahydrobiopterin (BH4) – Powder (Compounded), 50mg

Tetrahydrobiopterin (BH4) – Powder (Compounded), 50mg

$65.00

Uniform mixture of 50mg Tetrahydrobiopterin (BH4) and 950mg Ascorbic Acid for stability purposes. Total weight is 1000mg, or 1 gram. 20 mg of mixture is equivalent to 1 mg BH4. Please confirm total weight with a milligram scale on receipt.

WARNING: 1000mg is a small amount, less than a tablespoon.

Ships with thermal packaging. Not eligible for free shipping.

Bulk Pricing
1 2-4 5-9 10-19 20-49 50+
$65.00 $60.13 $55.25 $50.38 $45.50 $40.63
000

Read the Specification Before Buying:

Application Neurotransmitter Cofactor, Potent NO Scavenger
CAS 17528-72-2
Molar Mass 241.25 g/mol
 Chemical Formula C9H15N5O3
Chemical Name (6R)-2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(1H)-one
Synonyms Tetrahydrobiopterin, BH4, Kuvan, Sapropterin
Storage Freeze or refrigerate, keep away from light, minimize open air exposure
Solubility Water
Organoleptic Profile White to pale yellow fine powder
Physical Form Solid, uniform powder mixture with USP ascorbic acid (1:19) for stability.
Purity HNMR, TLC
Terms The products we offer are intended for laboratory research use only.
Please familiarize yourself with our Terms & Conditions prior to ordering.

Literature

  1. Protective effects of (6R) 5,6,7,8-tetrahydro-L-biopterin on local ischemia/reperfusion induced suppression of reactive hyperemia in rat gingiva: Y. Tanaka, et al. ; J. Clin. Biochem. Nutr. 58, 69 (2015), Abstract; Full Text
  2. Availability of tetrahydrobiopterin is not a factor in the inability to detect nitric oxide production by human macrophages: N. Sakai and S. Milstien; BBRC 193, 378 (1993), Abstract;
  3. Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP: G. Werner-Felmayer, et al.; J. Biol. Chem. 268, 1842 (1993), Abstract; Full Text
  4. Regulation of the L-arginine-dependent and tetrahydrobiopterin- dependent biosynthesis of nitric oxide in murine macrophages: G. Schoedon, et al.; Eur. J. Biochem. 213, 833 (1993), Abstract;
  5. Tetrahydrobiopterin and cytokines: E.R. Werner, et al.; Proc. Soc. Exp. Biol. Med. 203, 1 (1993), (Review), Abstract;
  6. Macrophage nitric oxide synthase: relationship between enzyme-bound tetrahydrobiopterin and synthase activity: J.M. Hevel & M.A. Marletta; Biochemistry 31, 7160 (1992), Abstract;
  7. Mechanistic probes of N-hydroxylation of L-arginine by the inducible nitric oxide synthase from murine macrophages: R.A. Pufahl, et al.; Biochemistry 31, 6822 (1992), Abstract;
  8. Stimulation of human nitric oxide synthase by tetrahydrobiopterin and selective binding of the cofactor: P. Klatt, et al.; FEBS Lett. 305, 160 (1992), Abstract;
  9. Tetrahydrobiopterin synthesis. An absolute requirement for cytokine- induced nitric oxide generation by vascular smooth muscle: S.S. Gross & R. Levi; J. Biol. Chem. 267, 25722 (1992), Abstract; Full Text
  10. Brain nitric oxide synthase is a biopterin- and flavin-containing multi- functional oxido-reductase: B. Mayer, et al.; FEBS Lett. 288, 187 (1991), Abstract;
  11. Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells: J.S. Pollock, et al.; PNAS 88, 10480 (1991), Abstract;
  12. Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginine: J. Giovanelli, et al.; PNAS 88, 7091 (1991), Abstract;
  13. Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages: N.S. Kwon et al.; J. Biol. Chem. 264, 20496 (1989), Abstract;

FAQ

Is it okay if my order arrived warm? If the gelpack is melted?
It’s nothing to worry about. We use the gelpack as a heat sink. The real risk is exposure to open air and moisture. As long as the product is tightly sealed with a desiccant and anti-oxidant it can remain stable for several weeks with little loss to potency.

Why do you mix BH4 with Vitamin C?
We mix BH4 with Vitamin C in a ratio of 1:19 to prevent oxidation and to make it easier to measure.

How much powder will I receive?
Each unit contains 1000mg powder mixture of 50mg BH4 and 950mg Ascorbic Acid. 1000mg is equivalent to 1 gram. 20 mg powder mixture is equivalent to 1 mg BH4. It is recommended you verify the total powder weight on receipt with a milligram scale. When measuring the powder there is a risk of loss in potency due to air exposure. If the exposure is

Cofactors of BH4?
​BH4 is itself a rate limiting enzyme cofactor, however, when applying exogenous sources, it may no longer be the rate limiting factor. Potential rate limiting cofactors include P5P, Tyrosine, and SAMe.

post->ID ), 'single-post-thumbnail' )[0]; $ItemId = $product->id; $Title = $product-> get_title(); $ProductUrl = "http://$_SERVER[HTTP_HOST]$_SERVER[REQUEST_URI]"; $Price = $product->get_price(); $RegularPrice = $product->get_regular_price(); $DiscountAmount = $RegularPrice - $Price; $terms = get_terms( 'product_tag' ); ?>