Uniform mixture of 50mg Tetrahydrobiopterin (BH4) and 950mg Ascorbic Acid for stability purposes. Total weight is 1000mg, or 1 gram. 20 mg of mixture is equivalent to 1 mg BH4. Please confirm total weight with a milligram scale on receipt.
WARNING: 1000mg is a small amount, less than a tablespoon.
Ships with thermal packaging. Not eligible for free shipping.
Read the Specification Before Buying:
|Application||Neurotransmitter Cofactor, Potent NO Scavenger|
|Molar Mass||241.25 g/mol|
|Synonyms||Tetrahydrobiopterin, BH4, Kuvan, Sapropterin|
|Storage||Freeze or refrigerate, keep away from light, minimize open air exposure|
|Organoleptic Profile||White to pale yellow fine powder, acidic taste.|
|Physical Form||Solid, uniform powder mixture with USP ascorbic acid (1:19) for stability.|
|Terms||The products we offer are intended for laboratory research use only.
Please familiarize yourself with our Terms & Conditions prior to ordering.
- Protective effects of (6R) 5,6,7,8-tetrahydro-L-biopterin on local ischemia/reperfusion induced suppression of reactive hyperemia in rat gingiva: Y. Tanaka, et al. ; J. Clin. Biochem. Nutr. 58, 69 (2015), Abstract; Full Text
- Availability of tetrahydrobiopterin is not a factor in the inability to detect nitric oxide production by human macrophages: N. Sakai and S. Milstien; BBRC 193, 378 (1993), Abstract;
- Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP: G. Werner-Felmayer, et al.; J. Biol. Chem. 268, 1842 (1993), Abstract; Full Text
- Regulation of the L-arginine-dependent and tetrahydrobiopterin- dependent biosynthesis of nitric oxide in murine macrophages: G. Schoedon, et al.; Eur. J. Biochem. 213, 833 (1993), Abstract;
- Tetrahydrobiopterin and cytokines: E.R. Werner, et al.; Proc. Soc. Exp. Biol. Med. 203, 1 (1993), (Review), Abstract;
- Macrophage nitric oxide synthase: relationship between enzyme-bound tetrahydrobiopterin and synthase activity: J.M. Hevel & M.A. Marletta; Biochemistry 31, 7160 (1992), Abstract;
- Mechanistic probes of N-hydroxylation of L-arginine by the inducible nitric oxide synthase from murine macrophages: R.A. Pufahl, et al.; Biochemistry 31, 6822 (1992), Abstract;
- Stimulation of human nitric oxide synthase by tetrahydrobiopterin and selective binding of the cofactor: P. Klatt, et al.; FEBS Lett. 305, 160 (1992), Abstract;
- Tetrahydrobiopterin synthesis. An absolute requirement for cytokine- induced nitric oxide generation by vascular smooth muscle: S.S. Gross & R. Levi; J. Biol. Chem. 267, 25722 (1992), Abstract; Full Text
- Brain nitric oxide synthase is a biopterin- and flavin-containing multi- functional oxido-reductase: B. Mayer, et al.; FEBS Lett. 288, 187 (1991), Abstract;
- Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells: J.S. Pollock, et al.; PNAS 88, 10480 (1991), Abstract;
- Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginine: J. Giovanelli, et al.; PNAS 88, 7091 (1991), Abstract;
- Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages: N.S. Kwon et al.; J. Biol. Chem. 264, 20496 (1989), Abstract;
Is it okay if my order arrived warm? If the gelpack is melted?
It’s nothing to worry about. We use the gelpack as a heat sink. The real risk is exposure to open air and moisture. As long as the product is tightly sealed with a desiccant and anti-oxidant it can remain stable for several weeks with little loss to potency.
Why do you mix BH4 with Vitamin C?
We mix BH4 with Vitamin C in a ratio of 1:19 to prevent oxidation and to make it easier to measure.
How much powder will I receive?
Each unit contains 1000mg powder mixture of 50mg BH4 and 950mg Ascorbic Acid. 1000mg is equivalent to 1 gram. 20 mg powder mixture is equivalent to 1 mg BH4. It is recommended you verify the total powder weight on receipt with a milligram scale. When measuring the powder there is a risk of loss in potency due to air exposure. If the exposure is
Cofactors of BH4?
BH4 is itself a rate limiting enzyme cofactor, however, when applying exogenous sources, it may no longer be the rate limiting factor. Potential rate limiting cofactors include P5P, Tyrosine, and SAMe.