TEMPOL – Powder (Compounded), 1000mg

TEMPOL – Powder (Compounded), 1000mg

$50.00

Uniform mixture of 1g TEMPOL and 10g Ascorbic Acid for stability purposes.

Ships with thermal packaging. Not eligible for free shipping.

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000

Read the Specification Before Buying:

Application SOD Mimetic
CAS 2226-96-2
Molar Mass 172.25 g/mol
 Chemical Formula C9H18NO2
Chemical Name 1-λ1-oxidanyl-2,2,6,6-tetramethylpiperidin-4-ol
Synonyms 4-Hydroxy-TEMPO, TEMPOL, 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl
Storage Freeze or refrigerate, keep away from light, minimize open air exposure
Solubility Water, Ethanol, Methanol
Organoleptic Profile White, orange-speckled powder, hygroscopic
Physical Form Solid, uniform powder mixture with USP ascorbic acid (1:10) for stability.
Reports HPLC
Terms The products we offer are intended for laboratory research use only.
Please familiarize yourself with our Terms & Conditions prior to ordering.

Literature

  1. Therapeutic targeting of mitochondrial superoxide in hypertension: A.E. Dikalova, et al.; Circ. Res. 107, 106 (2010),Abstract;
  2. Mitochondrial oxidative stress and dysfunction in myocardial remodelling: H. Tsutsui, et al.; Cardiovasc. Res. 81, 449 (2009), Abstract; Full Text
  3. A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria: J. Trnka, et al.; Free Radic. Biol. Med. 44, 1406 (2008), Abstract;
  4. TNF-alpha-induced mitochondrial oxidative stress and cardiac dysfunction: restoration by superoxide dismutase mimetic Tempol: N. Mariappan, et al.; Am. J. Physiol. Heart Circ. Physiol. 293, H2726 (2007), Abstract;
  5. Acute effects of the superoxide dismutase mimetic tempol on split kidney function in two-kidney one-clip hypertensive rats: G.S. Guron, et al.; J. Hypertens. 24, 387 (2006), Abstract;
  6. Neuroprotective effects of the stable nitroxide compound Tempol on 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in the Nerve Growth Factor-differentiated model of pheochromocytoma PC12 cells: T. Lipman, et al.; Eur. J. Pharmacol. 549, 50 (2006), Abstract;
  7. Probing the intracellular redox status of tumors with magnetic resonance imaging and redox-sensitive contrast agents: F. Hyodo, et al.; Cancer Res. 66, 9921 (2006), Abstract;
  8. TEMPOL, a membrane-permeable radical scavenger, attenuates peroxynitrite- and superoxide anion-enhanced carrageenan-induced paw edema and hyperalgesia: a key role for superoxide anion: M.M. Khattab; Eur. J. Pharmacol.548, 167 (2006), Abstract;
  9. The effects of tempol, 3-aminobenzamide and nitric oxide synthase inhibitors on acoustic injury of the mouse cochlea: H. Murashita, et al.; Hear. Res. 214, 1 (2006), Abstract;
  10. The nitroxide Tempol modulates anthracycline resistance in breast cancer cells: M.B. Gariboldi, et al.; Free Radic. Biol. Med. 40, 1409 (2006), Abstract;
  11. The role of oxidant stress in angiotensin II-mediated contraction of human resistance arteries in the state of health and the presence of cardiovascular disease: M.B. Hussain, et al.; Vascul. Pharmacol. 45, 395 (2006), Abstract;
  12. Antioxidant enzymes and effects of tempol on the development of hypertension induced by nitric oxide inhibition: J. Sainz, et al.; Am. J. Hypertens. 18, 871 (2005), Abstract;
  13. Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor: L. Erker, et al.; Hum. Mol. Genet. 14, 1699 (2005), Abstract;
  14. Neuroprotective effects of TEMPOL in central and peripheral nervous system models of Parkinson’s disease: Q. Liang, et al.; Biochem. Pharmacol. 70, 1371 (2005), Abstract;
  15. Systemic arterial pressure response to two weeks of Tempol therapy in SHR: involvement of NO, the RAS, and oxidative stress: L. Yanes, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 288, R903 (2005), Abstract;
  16. Tempol, one of nitroxides, is a novel ultraviolet-A1 radiation protector for human dermal fibroblasts: S.X. Yan, et al.; J. Dermatol. Sci. 37, 137 (2005), Abstract;
  17. Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats: H. Xu et al.; Hypertension 43, 329 (2004), Abstract;
  18. The superoxide dismutase mimetic, tempol, blunts right ventricular hypertrophy in chronic hypoxic rats: B. Elmedal et al.; Br. J. Pharmacol. 141, 105 (2004), Abstract;
  19. Nitroxide TEMPOL impairs mitochondrial function and induces apoptosis in HL60 cells: E. Monti, et al.; J. Cell. Biochem.82, 271 (2001), Abstract;
  20. Spin trapping agents (Tempol and POBN) protect HepG2 cells overexpressing CYP2E1 against arachidonic acid toxicity: M.J. Perez & A.I. Cederbaum; Free Radic. Biol. Med. 30, 734 (2001), Abstract;
  21. The nitroxide tempol induces oxidative stress, p21(WAF1/CIP1), and cell death in HL60 cells: M.B. Gariboldi, et al.; Free Radic. Biol. Med. 29, 633 (2000), Abstract;
  22. Effects of the superoxide dismutase-mimic compound TEMPOL on oxidant stress-mediated endothelial dysfunction: A.I. Haj-Yehia, et al.; Antioxid. Redox Signal. 1, 221 (1999), Abstract;
  23. Stable nitroxide radicals protect lipid acyl chains from radiation damage: A.M. Samuni & Y. Barenholz; Free Radic. Biol. Med. 22, 1165 (1997), Abstract;
  24. Tempol inhibits neutrophil and hydrogen peroxide-mediated DNA damage: S.M. Hahn, et al.; Free Radic. Biol. Med. 23, 879 (1997), Abstract;
  25. A novel antioxidant alleviates heat hyperalgesia in rats with an experimental painful peripheral neuropathy: M. Tal; Neuroreport 7, 1382 (1996), Abstract;
  26. Protective effect of 4-hydroxy-TEMPO, a low molecular weight superoxide dismutase mimic, on free radical toxicity in experimental pancreatitis: Z. Sledzinski, et al.; Int. J. Pancreatol. 18, 153 (1995), Abstract;
  27. Tempol, a stable free radical, is a novel murine radiation protector: S.M. Hahn, et al.; Cancer Res. 52, 1750 (1992),Abstract;
  28. Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, tempol: J.B. Mitchell, et al.; Arch. Biochem. Biophys. 289, 62 (1991), Abstract;
  29. Measurement of intracellular oxygen concentration using the spin label TEMPOL: P.D. Morse, 2nd & H.M. Swartz; Magn. Reson. Med. 2, 114 (1985), Abstract;

FAQ

Is it okay if my order arrived warm? If the gelpack is melted?
It’s nothing to worry about. We use the gelpack as a heat sink. The real risk is exposure to open air and moisture. As long as the product is tightly sealed with a desiccant and anti-oxidant it can remain stable for several weeks with little loss to potency.
Why do you mix with Ascorbic Acid (Vitamin C)?
Ascorbic acid is used for stability and convenience purposes. Ascorbic acid prevents oxidation and dilution makes measurement easier.